https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43761 Quest cultivar, but the Fe concentration in rice tissues showed the reverse order. Fe plaque formations were promoted by Fe application, which was 7.8 and 10.4 times higher at 1 and 2 g kg-1 Fe applications compared to the control Fe treatment. The Quest cultivar exhibited 13% higher iron plaque formation capacity compared to the Langi cultivar in both soil types. These results indicate that enhanced iron plaque formation on the root surface was crucial to reduce the Cd concentration in rice plants, which could be an effective strategy to regulate grain Cd accumulation in rice plants.]]> Wed 28 Sep 2022 15:44:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17766 80Zr₂₀ metallic glass during melt quenching are studied by molecular dynamics simulation using statistical-geometrical analysis based on Voronoi polyhedra and cluster analysis. The morphology and size distribution of polyhedral nanoclusters in the glass structure are investigated.]]> Wed 19 Oct 2022 15:15:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41157 Wed 15 Feb 2023 10:57:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30189 Hfe^−/−xTfr2^mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.]]> Wed 11 Apr 2018 16:58:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14032 Wed 11 Apr 2018 16:55:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22505 Wed 11 Apr 2018 16:25:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19355 Wed 11 Apr 2018 11:43:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8722 Wed 11 Apr 2018 11:13:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14512 120 g/L) and iron-sufficient young women (18–35 years). Cognitive function and haematological markers of iron status were measured at baseline and follow-up. Iron-deficient participants (n = 24) were randomised to receive placebo, 60 mg or 80 mg elemental iron daily supplements for 16 weeks. A control group of iron-sufficient participants (n = 8) was allocated to placebo. Change scores for Impulsivity and Attention were significantly greater in plasma ferritin improvers than in non-improvers (p = 0.004, p = 0.026). IntegNeuro was easy to administer and acceptable to young women. Based on the differences in Memory and Attention scores between iron-deficient participants on iron treatment and those on placebo, it was decided that between 26 and 84 participants would be required in each iron treatment group for an adequately powered extension of this pilot RCT.]]> Wed 11 Apr 2018 10:25:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15828 Wed 11 Apr 2018 10:13:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31006 Wed 02 Mar 2022 14:28:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39295 1) and carcinogenic risks (CR > 1.0 × 10−4) increased with increasing Cd levels in the soil. The application of Fe decreased the human health risks from rice consumption which is more pronounced in Fe 2.0 than in Fe1.0 treatments. The rice cultivar grown in soil-1 (pH 4.6) showed the highest health risks as compared to soil-2 (pH 6.6) and the Quest cultivar had lower health risks than the Langi cultivar.]]> Tue 31 Oct 2023 11:13:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46340 −1 (Bangladesh drinking water standard) during pre-monsoon, while 11 samples out of 20 were unable to remove As below the WHO provisional guideline value of 10 µg L⁻¹. During post-monsoon, none of the samples exceeded 50 µg L−1, but eight of them exceeded 10 µg L⁻¹. The Fe removal efficiencies of AIRPs were evident in more than 80% samples. Although As removal efficiency was found to be substantial, a cancer risk assessment indicates that hazard quotient (HQ) and carcinogenic risk (CR) of As in treated water for adults and children are above the threshold limits. Thus, additional reductions of As concentrations in treated water are needed to further reduce the excess cancer risk due to As in drinking water. Since 55% and 40% of the AIRPs were unable to remove As < 10 µg L⁻¹ during pre-monsoon and post-monsoon, further improvement including changes in AIRP design, regular cleaning of sludge, and periodic monitoring of water quality are suggested. Future research is needed to determine whether these modifications improve the performance of AIRPs.]]> Tue 15 Nov 2022 15:04:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47043 Tue 13 Dec 2022 14:22:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40424 Tue 12 Jul 2022 08:56:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34458 Tue 03 Sep 2019 18:22:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50558 Tue 01 Aug 2023 10:33:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33862 Thu 25 Jun 2020 11:51:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:590 Thu 25 Jul 2013 09:10:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43992 Thu 24 Aug 2023 09:52:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36161 Thu 20 Feb 2020 14:45:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49473 Thu 18 May 2023 14:48:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43353 400 nm) and solar light irradiation. The role of hydrogen peroxide to enhance the catalyst’s efficiency was examined. The reaction pathway of complete mineralization was investigated by monitoring the temporal evolution of reaction intermediates and low molecular weight organic acids (LMWOA) as final products in solution. These LMWOAs are oxidized eventually to inorganic ions such a nitrate, sulfate, oxalate etc, which are confirmed using GC–MS, UV–Vis and Ion Chromatographic analyses. The optimized conditions of photocatalytic degradation were obtained for degradation under different light source. The Fe-doped TiO2 showed high dye degradation efficiency under both UV (100%), visible (100%) and solar light (90%) which distinguishes Fe-doped TiO2 from materials in literature that are only efficient in particular light source for dye degradation. Furthermore, the Fe doped titania photocatalysts are stable and can maintain performance up to 6 recycle use. Reaction kinetics for UV and solar light induced degradation followed first order reaction whereas visible light degradation followed a zero-order reaction.]]> Thu 15 Sep 2022 15:32:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10312 0.05). In participants without dementia (n=749), neither serum ferritin in 1994/5 or 2003/4 nor change in serum ferritin between these times was related to total CAMCOG or executive function scores, with or without adjustment for gender, age, National Adult reading test, or stroke history (all p> 0.05). No relationships were observed between ferritin and cognition for participants with possible or probable dementia (n=51). All participants identified as HFE C282Y homozygous or with serum ferritin >1,000 ng/ml had normal CAMCOG scores. We conclude abnormal body iron stores (low or high) are unlikely to have clinically significant effects on cognition or dementia risk in community-dwelling older people.]]> Sat 24 Mar 2018 08:12:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10036 Sat 24 Mar 2018 08:12:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10807 Sat 24 Mar 2018 08:11:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11480 Sat 24 Mar 2018 08:10:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10479 Sat 24 Mar 2018 08:09:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20882 -/- mice, a model of hemochromatosis, relative to age- and gender-matched wildtype controls. Classification by functional pathway analysis revealed transcript changes for various genes important in AD. There were decreases of up to 9-fold in transcripts for amyloid-β protein precursor, tau, apolipoprotein E, presenilin 1, and various other γ-secretase components, as well as Notch signaling pathway molecules. This included decreased transcripts for 'hairy and enhancer of split' Hes1 and Hes5, downstream targets of Notch canonical signaling. The reductions in Hes1 and Hes5 transcripts provide evidence that the changes in levels of transcripts for γ-secretase components and Notch signaling genes have functional consequences. The effects appeared relatively specific for AD in that few genes pertaining to other important neurodegenerative diseases, notably Parkinson's disease and Huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. The observed effects on AD-related gene transcripts do not appear to be consistent with increased AD risk in HFE hemochromatosis and might, if anything, be predicted to protect against AD to some extent. As Hfe^-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading.]]> Sat 24 Mar 2018 07:57:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19747 transferrin (TF) C2 polymorphism modifies the effects of lead and hemoglobin on intelligence. Methods: Children aged 3–7 years (N = 708) were enrolled from 12 primary schools in Chennai, India. The Binet–Kamath Scale of Intelligence were administered to ascertain intelligence quotient (IQ). Venous blood was analyzed for lead and hemoglobin levels. Genotyping for the TF C2 polymorphism (rs1049296) was carried out using a MassARRAY iPLEXTM platform. Stratified analyses and interaction models, using generalized estimating equations, were examined to explore interactions between lead, hemoglobin, and TF C2 categories. Results: A one-unit increase in log blood lead and 1 g/dl higher hemoglobin was associated with −77 (95% CI: −136, −18) and 17 (95% CI 14, 21) IQ points, respectively, among children carrying the C2 variant. In comparison, among children who had the homozygous wildtype allele, the same increment of lead and hemoglobin were associated with −21(95% CI: −65, 24) and 28 (95% CI: 15, 40) IQ points, respectively. There was a significant interaction between lead (p = 0.04) and hemoglobin (p = 0.07) with the C2 variant. Conclusion: Children who carry the TF C2 variant may be more susceptible to the neurotoxic effects of lead exposure and less protected by higher levels of hemoglobin.]]> Sat 24 Mar 2018 07:53:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21833 HFE gene. There is evidence from both human and animal studies that HFE gene variants may affect brain function and modify risks of brain disease. To investigate how disruption of HFE influences brain transcript levels, we used microarray and real-time reverse transcription polymerase chain reaction to assess the brain transcriptome in Hfe^−/− mice relative to wildtype AKR controls (age 10 weeks, n ≥ 4/group). The Hfe^−/− mouse brain showed numerous significant changes in transcript levels (p < 0.05) although few of these related to proteins directly involved in iron homeostasis. There were robust changes of at least 2-fold in levels of transcripts for prominent genes relating to transcriptional regulation (FBJ osteosarcoma oncogene Fos, early growth response genes), neurotransmission (glutamate NMDA receptor Grin1, GABA receptor Gabbr1) and synaptic plasticity and memory (calcium/calmodulin-dependent protein kinase IIα Camk2a). As previously reported for dietary iron-supplemented mice, there were altered levels of transcripts for genes linked to neuronal ceroid lipofuscinosis, a disease characterized by excessive lipofuscin deposition. Labile iron is known to enhance lipofuscin generation which may accelerate brain aging. The findings provide evidence that iron loading disorders can considerably perturb levels of transcripts for genes essential for normal brain function and may help explain some of the neurologic signs and symptoms reported in hemochromatosis patients.]]> Sat 24 Mar 2018 07:52:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19405 Sat 24 Mar 2018 07:52:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16936 Sat 24 Mar 2018 07:51:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5556 Sat 24 Mar 2018 07:49:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30787 Sat 24 Mar 2018 07:37:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28439 75th percentile (≥43 µg/l) (OR 1.49, 95 % CI 1.06, 2.10) and >90th percentile (≥68 µg/l) (OR 1.92, 95 % CI 1.25, 2.96). Increased odds of early and moderate-to-late sPTB were associated with ferritin levels >90th percentile (OR 2.50, 95 % CI 1.32, 4.73) and >75th percentile (OR 1.56, 95 % CI 1.03, 2.37), respectively. No association was found between the risk of sPTB and elevated sTfR levels or Fe deficiency. In conclusion, elevated maternal serum ferritin levels in early pregnancy are associated with an increased risk of sPTB from 34 weeks of gestation. The usefulness of early pregnancy ferritin levels in identifying women at risk of sPTB warrants further investigation.]]> Sat 24 Mar 2018 07:29:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4888 Sat 24 Mar 2018 07:21:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4870 Sat 24 Mar 2018 07:18:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23144 mut), a model of a rare type of hereditary hemochromatosis, relative to wildtype control mice. The results were compared with our previous findings in dietary iron-supplemented wildtype mice and Hfe^−/− mice, a model of a common type of hereditary hemochromatosis. For transcripts showing significant changes relative to controls across all three models, there was perfect (100%) directional concordance (i.e. transcripts were increased in all models or decreased in all models). Comparison of the two models of hereditary hemochromatosis, which showed more pronounced changes than the dietary iron-supplemented mice, revealed numerous common molecular effects. Pathway analyses highlighted changes for genes relating to long-term depression (6.8-fold enrichment, p = 5.4 × 10⁻⁷) and, to a lesser extent, long-term potentiation (3.7-fold enrichment, p = 0.01), with generalized reductions in transcription of key genes from these pathways, which are involved in modulating synaptic strength and efficacy and are essential for memory and learning. The agreement across the models suggests the findings are robust and strengthens previous evidence that iron loading disorders affect the brain. Perturbations of brain phenomena such as long-term depression and long-term potentiation might partly explain neurologic symptoms reported for some hemochromatosis patients.]]> Sat 24 Mar 2018 07:10:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37154 Desmodesmusv sp. MAS1 and Heterochlorella sp. MAS3, grown in synthetic acid mine drainage (SAMD). Virtually, there was no difference in the growth of the strain MAS3 both in Bold's basal medium (control) and SAMD. Using the IC₅₀ level (200 mg L^-1) and a lower concentration (50 mg L^-1) of iron in SAMD, the cell granularity, exopolysaccharide (EPS) secretion, iron recovery, and biodiesel were assessed in both the strains. Both cell granularity and accumulation of EPS were significantly altered under metal stress in SAMD, resulting in an increase in total accumulation of iron. Growth of the microalgal strains in SAMD yielded 12-20% biodiesel, with no traces of heavy metals, from the biomass. The entire amount of iron, accumulated intracellularly, was recovered in the residual biomass. Our results on the ability of the acid-adapted microalgal strains in iron recovery and yield of biodiesel when grown in SAMD indicate that they could be the potential candidates for use in bioremediation of extreme habitats like AMD.]]> Mon 24 Aug 2020 12:48:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32188 PMS. Increasing acidity and iron dosage favored a rapid degradation of AO7. The presence of chloride greatly inhibited dye removal in Fe⁰/H₂O₂ and Fe⁰/PS systems, whilst accelerated dye degradation was observed in the Fe⁰/PMS system. In contrast, mineralization of AO7 in the Fe⁰/PMS/Cl- system was minimal, because of formation of lots of refractory chlorinated phenols as identified by GC-MS. These findings are useful for selecting the most appropriate technology for textile wastewater treatment, depending on the wastewater constituents and pH.]]> Mon 23 Sep 2019 11:21:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33233 Mon 23 Sep 2019 10:39:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36313 Mon 23 Aug 2021 12:41:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39219 HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. Methods: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2* measures (lower values indicating more iron). Results: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2* measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. Conclusion: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.]]> Fri 27 May 2022 11:37:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52954 Fri 03 Nov 2023 11:04:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36754 1 for arsenic in the tube wells water of seven Upazilas at Satkhira district. Lifetime drinking of arsenic-contaminated water may trigger cancer risk to the human health.]]> Fri 03 Jul 2020 09:54:41 AEST ]]>